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The resulting protein was centrifuged to remove any aggregates and loaded onto a Superdex 200 16/600 size exclusion chromatography (SEC) column equilibrated in SEC buffer for crystallisation (10 mM Tris-HCl pH 8.0, 200 mM KCl, 0.5 mM PMSF, 1 mM TCEP) 31 or NMR (50 mM mono/dibasic sodium phosphate buffer pH 8.0, 150 mM NaCl, 1 mM TCEP)

11 (1) DOI: 10.1038/s41514-025-00244-x Cite This Page : ScienceDaily

Current Availability and FDA Status As of now, Retatrutide is still under clinical investigation, and its availability is limited

you're simply changing the source and cost structure of the same active ingredient